Table 1.
Result of isobolographic analysis showing CI of DOX in the presence of different concentrations of XN in MCF-7/ADR cells. The CI values were calculated by CompuSyn (ComboSyn, Inc., Paramus, NJ, USA).
| XN (μM) | DOX (μM) | Effect | CI |
|---|---|---|---|
| 2.5 | 1.25 | 0.026 | 1.16 |
| 2.5 | 2.5 | 0.03 | 1.27 |
| 2.5 | 5 | 0.1 | 0.85 |
| 2.5 | 10 | 0.25 | 0.66 |
| 2.5 | 20 | 0.26 | 0.97 |
| 2.5 | 40 | 0.35 | 1.26 |
| 5 | 1.25 | 0.16 | 0.87 |
| 5 | 2.5 | 0.31 | 0.62 |
| 5 | 5 | 0.58 | 0.41 |
| 5 | 10 | 0.53 | 0.52 |
| 5 | 20 | 0.54 | 0.67 |
| 5 | 40 | 0.84 | 0.42 |
| 10 | 1.25 | 0.18 | 1.56 |
| 10 | 2.5 | 0.53 | 0.77 |
| 10 | 5 | 0.58 | 0.74 |
| 10 | 10 | 0.62 | 0.75 |
| 10 | 20 | 0.87 | 0.44 |
| 10 | 40 | 0.90 | 0.47 |