Table 1.

Cytotoxic activity of acetylenic quinolines and cisplatin as a reference compound.

Compound	Human Cell Line/IC50 ± SD [µM]
	MCF-7	T47D	MDA-MB-231	HFF-1
2a	351.36 ± 6.32	neg 1	139.82 ± 1.98	neg
2b	22.89 ± 1.45	0.30 ± 0.03	0.24 ± 0.01	neg
2c	0.17 ± 0.02	2.24 ± 0.11	0.27 ± 0.02	85.37 ± 1.60
2d	233.84 ± 1.56	292.04 ± 2.34	180.27 ± 2.35	425.17 ± 1.46
2e	1.29 ± 0.09	26.80 ± 0.67	59.31 ± 1.56	neg
2f	61.22 ± 1.65	295.64 ± 2.56	204.08 ± 3.10	153.40 ± 3.0
5a	287.87 ± 3.45	neg	11.75 ± 0.87	neg
5b	18.36 ± 0.98	181.81 ± 3.23	0.27 ± 0.03	neg
5c	neg	205.36 ± 6.02	116.15 ± 2.13	neg
5d	236.81 ± 2.34	neg	202.00 ± 5.46	neg
5e	0.27 ± 0.03	0.21 ± 0.01	7.12 ± 0.78	276.06 ± 2.60
5f	13.09 ± 0.11	0.27 ± 0.03	21.21 ± 0.96	366.06 ± 1.46
6a	237.93 ± 2.11	146.26 ± 1.98	0.42 ± 0.01	neg
6b	22.72 ± 0.12	10.58 ± 0.15	1.32 ± 0.12	92.85 ± 2.0
6c	112.67	313.48 ± 7.98	17.56 ± 0.87	neg
6d	259.25 ± 5.45	neg	0.68 ± 0.09	330.95 ± 4.0
6e	108.75 ± 2.11	159.86 ± 3.23	23.46 ± 1.02	neg
6f	0.26 ± 0.01	55.63 ± 1.78	64.47 ± 1.98	317.46 ± 5.46
11	7.36 ± 0.45	126.84 ± 2.01	8.73 ± 0.78	175.83 ± 3.0
12	3.14 ± 0.34	2.50 ± 0.09	2.86 ± 0.34	375.47 ± 3.0
14	118.29 ± 2.04	11.73 ± 1.11	26.83 ± 1.45	71.76 ± 1.60
Cisplatin	77.76 ± 0.76	30.26 ± 0.34	17.63 ± 0.31	7.2 ± 0.60

¹ Negative in concentration used.