Table 3.
The activity of non-antibiotics (active substances and medicinal products) against clinical isolates of Enterobacteriaceae and non-fermentative Gram-negative rods.
| Bacteria (No. of Strains) | Non-Antibiotic Active Substance (Medicinal Product) | No. of Isolates with MIC Values | |||
|---|---|---|---|---|---|
| 200 mg/L | 400 mg/L | 800 mg/L | >800 mg/L | ||
| E. coli (n = 36) | amitriptyline (Amitriptylinum) | 7 (7) | 27 (27) | 2 (2) | 0 (0) |
| K. pneumoniae (n = 36) | amitriptyline (Amitriptylinum) | 23 (23) | 13 (13) | 0 (0) | 0 (0) |
| P. aeruginosa (n = 36) | alendronate (Ostenil) | 33 (33) a | 3 (3) | 0 (0) | 0 (0) |
| amitriptyline (Amitriptylinum) | 0 (0) | 0 (0) | 36 (36) | 0 (0) | |
| carboplatin (Carbosin) | 0 (0) | 6 (6) | 29 (29) | 1 (1) | |
| S. maltophilia (n = 36) | alendronate (Ostenil) | 10 (10) | 17 (16) | 9 (10) | 0 (0) |
| amitriptyline (Amitriptylinum) | 33 (33) a | 3 (3) | 0 (0) | 0 (0) | |
| A. baumannii (n = 36) | amitriptyline (Amitriptylinum) | 36 (36) | 0 (0) | 0 (0) | 0 (0) |
a In the case of P. aeruginosa and S. maltophilia, for several strains (7 out of 33, and 2 out of 33, respectively) sensitivity to alendronate/Ostenil and amitriptyline/Amitriptylinum below 200 mg/L (MIC = 100 mg/L) was observed.