Table 4.
Effects of PAβN on the MIC values of tested non-antibiotics against clinical isolates of Enterobacteriaceae and non-fermentative Gram-negative rods.
| Bacteria (No. of Strains) | Non-Antibiotic Substance (Medicinal Product) | No. of Isolates with Indicated Fold Reduction in Non-Antibiotic MICs in the Presence of PAβN | ||||
|---|---|---|---|---|---|---|
| ≥4-Fold | ≥8-Fold | ≥16-Fold | ≥32-Fold | ≥64-Fold | ||
| E. coli (n = 36) | alendronate (Ostenil) | 36 (36) | 36 (35) | 28 (26) | 0 (0) | 0 (0) |
| ticlopidine (Apo-Clodin) | 36 (36) | 36 (36) | 36 (36) | 36 (36) | 36 (36) | |
| amitriptyline (Amitriptylinum) | 36 (36) | 28 (28) | 4 (4) | 1 (1) | 0 (0) | |
| nicergoline (Niglostin) | 36 (36) | 36 (36) | 26 (25) | 0 (0) | 0 (0) | |
| K. pneumoniae (n = 36) | alendronate (Ostenil) | 30 (30) | 19 (18) | 0 (0) | 0 (0) | 0 (0) |
| ticlopidine (Apo-Clodin) | 36 (36) | 36 (36) | 36 (36) | 33 (33) | 31 (30) | |
| amitriptyline (Amitriptylinum) | 27 (27) | 2 (1) | 1 (0) | 0 (0) | 0 (0) | |
| nicergoline (Niglostin) | 30 (30) | 28 (28) | 7 (6) | 0 (0) | 0 (0) | |
| P. aeruginosa (n = 36) | alendronate (Ostenil) | 28 (28) | 17 (16) | 1 (1) | 0 (0) | 0 (0) |
| amitriptyline (Amitriptylinum) | 21 (21) | 16 (15) | 10 (10) | 4 (3) | 0 (0) | |
| carboplatin (Carbosin) | 16 (16) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| S. maltophilia (n = 36) | ticlopidine (Apo-Clodin) | 33 (33) | 21 (21) | 16 (16) | 13 (13) | 4 (3) |
| A. baumannii (n = 36) | ticlopidine (Apo-Clodin) | 30 (30) | 27 (27) | 24 (24) | 21 (21) | 8 (7) |
| amitriptyline (Amitriptylinum) | 24 (24) | 3 (2) | 1 (0) | 0 (0) | 0 (0) | |
| nicergoline (Niglostin) | 36 (36) | 36 (36) | 11 (10) | 1 (0) | 0 (0) | |
PAβN, efflux pump inhibitor Phe-Arg-β-naphthylamide.