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Evidence of plasma extravasation after SpA challenge in VHIII Fab-IgG2a treated mice. Wild type C57BL/6 mice received Evans Blue dye (0.5% w/v) then were infused with 1 mg VHIII IgG2a and 24 h later i.v. injection of 1 mg SpA or ovalbumin (OVA) or sham (PBS) treatment, as indicated. The ears of representative mice in each group are shown.
