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. 2018 Sep 25;17:1536012118795952. doi: 10.1177/1536012118795952

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Binding affinity of [¹¹C]CEP-32496 in BRAF^V600E-positive melanoma cells. The IC₅₀ values of [¹¹C]CEP-32496 uptake were calculated by nonlinear regression analysis using Prism 5. The binding assay of [¹¹C]CEP-32496 was performed with different concentrations (0-10³ μM) of unlabeled CEP-32496 or sorafenib. Data are expressed as means ± standard error of mean (SEM), based on 3 independent experiments.