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. 2018 Sep 25;17:1536012118795952. doi: 10.1177/1536012118795952

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — [¹¹C]CEP-32496 binding in BRAF^V600E-positive A375-tumor tissue sections. A, In vitro autoradiograms. Dense radioactivity of [¹¹C]CEP-32496 is present in A375 xenografts. The BRAF^V600E antagonist sorafenib or unlabeled CEP-32496 specifically blocked the uptake of [¹¹C]CEP-32496. B, Quantification of radioactivity levels in the autoradiograms. Intergroup comparisons were performed using 1-way analysis of variance test. Asterisks indicate statistical significance (**P < .01). Data are expressed as means ± standard error of mean (SEM), based on 3 independent experiments.