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. 2018 Sep 25;9:3916. doi: 10.1038/s41467-018-06449-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — VX-765 reverses loss of synaptophysin in J20 mice. a Synaptophysin immunopositive micrographs. Scale bar = 200 µm for hippocampus and 50 µm for cortex. b Synaptophysin immunopositive density in WT + vehicle (grey squares, n = 4), J20 + vehicle (black circles, n = 4), and J20 + VX-765 (blue triangles, n = 4) hippocampus (F(2,9) = 7.974, p = 0.0102, ANOVA, Tukey’s post-hoc, **p < 0.01) and cortex. c Significantly altered (Kruskall−Wallis) synaptic protein mRNA levels in vehicle or VX-765-treated J20 mice hippocampi (n = 3 per group)