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. 2018 Sep 25;8:14335. doi: 10.1038/s41598-018-32729-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Eed deletion activates expression of non-TEC transcriptional signatures. (a) Gene expression correlation of tissue-specific genes in Eed^CKO and control TEC. AltAnalyze LineageProfiler was used to correlate the transcriptional profiles of lineage-specific markers with gene expression in Eed^CKO and control TEC. The log₂FPKM values of Eed^CKO DEG were used as input to identify differences of lineage-specific expression profiles. Correlation coefficients were z-score normalized to plot the heatmap. (b) Mesenchymal stem cell differentiation pathway genes and (c) neural stem cell differentiation pathway genes were collected from PathCards (http://pathcards.genecards.org/). From these genes, Eed^CKO DEG were selected and z-score normalized log₂FPKM values were used to plot the heatmaps.