Figure 4.

The reversing effect of Lycium barbarum polysaccharides (LBPs) on cardiac structural remodelling produced by miR‐1 overexpression. A, The change of bodyweight in three groups. *P < .05 vs WT, ^# P < .05 vs Tg; mean ± SEM, n = 13 for WT, 12 for Tg, and 7 for LBPs. B, The change of ratio of heart to bodyweight in three groups. **P < .01 vs WT; mean ± SEM, n = 13 for WT, 12 for Tg, and 7 for LBPs. C, Longitudinal sections of hearts stained by H&E from mice of three groups, scale bar: 5 mm. D, TEM examination of cardiac myofilament showing sarcomeric length, clear zone and H‐zone, and myofibrillar fragmentation and dissolution (in Tg mice). Up panels: magnification ×5000, scale bar: 2 μm and down panels: magnification ×12 000, scale bar: 2 μm. E, Comparison of length and variation of sarcomeres. **P < .01 vs WT, ^## P < .01 vs Tg, data presented as mean ± SD (for variation), n = 80 from three hearts for each group