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. 2018 Sep 19;9:2141. doi: 10.3389/fimmu.2018.02141

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Copyright © 2018 Plens-Galaska, Szelag, Collado, Marques, Vallejo, Ramos-González, Wesoly, Sanz, Peiró and Bluyssen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C01L_F03, STATTIC and STX-0119 inhibit IFNγ+LPS induced gene expression of IFIT2, OAS2, CCL5, CXCL10, CXCL9, ICAM1, and VCAM1. HMECs were treated with (A) 50, 25, 10 μM of C01L_F03 for 48 h or (B) 10, 5, 2.5 μM of STATTIC for 8 h or (C) with 25, 12.5, 6.25 μM of STX-0119 for 24 h and for 8 h with IFNγ + 4 h with LPS. RNA was isolated and subjected to qPCR analysis. Experiments were performed in 3 individual repeats, which were compared by two-way ANOVA test and unpaired two-tailed student T-test.