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. 2018 Jul 31;22(10):4948–4962. doi: 10.1111/jcmm.13759

Figure 6.

Figure 6

BCAA induce endothelial dysfunction through ROS. A, Contraction to depolarizing solution of high KCl (K+‐KHS) in arteries incubated with BCAA (6 mmol/L, 24 h) in the absence or presence of different antioxidants: gp91dstat, ML171, and mito‐TEMPO. Concentration‐response curves to phenylephrine (Phe) (B), acetylcholine (ACh) (C) and diethylamine NONOate (DEA‐NO) (D) in aortic segments incubated with BCAA in the absence or presence of gp91dstat, ML171 and mito‐TEMPO. Data represent mean ± SEM. *P < .05; ***P < .001 vs Control; ≠ P < .05; ≠≠ P < .01; ≠≠≠ P < .001 vs BCAA.