TABLE 3.
Distribution of 4 major respiratory pathogens collected from adults with COPD, Buffalo Veterans Affairs Medical Center, Buffalo, NY, USA, 1994 to 2014
| Parameter | Value [no. (%)] for participants in study for: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | <1 yr |
1–3 yr |
>3–5 yr |
>5–10 yr |
>10 yr |
||||||
| Stable | Exacb | Stable | Exac | Stable | Exac | Stable | Exac | Stable | Exac | ||
| Participants | 181 | 32 (18) | 50 (28) | 34 (19) | 49 (27) | 16 (9) | |||||
| Visitsa | 8,843 | 155 | 37 | 819 | 184 | 1,252 | 220 | 3,171 | 540 | 2,150 | 425 |
| Bacteria present | |||||||||||
| 0 pathogens | 6,231 (70) | 130 (84) | 33 (89) | 673 (82) | 121 (66) | 884 (71) | 117 (53) | 2,236 (71) | 308 (57) | 1,490 (69) | 239 (56) |
| 1 pathogen | |||||||||||
| S. pneumoniae | 247 (2.8) | 4 (2.6) | 2 (5.4) | 27 (3.3) | 11 (6.0) | 7 (0.56) | 3 (1.4) | 55 (1.7) | 20 (3.7) | 101 (4.7) | 17 (4.0) |
| M. catarrhalis | 380 (4.3) | 3 (1.9) | 1 (2.7) | 26 (3.2) | 16 (8.7) | 36 (2.9) | 20 (0.1) | 76 (2.4) | 35 (6.5) | 114 (5.3) | 53 (13) |
| P. aeruginosa | 579 (6.5) | 5 (3.2) | 1 (2.7) | 10 (1.2) | 2 (1.1) | 98 (7.8) | 26 (12) | 246 (7.8) | 40 (7.4) | 116 (5.4) | 35 (8.2) |
| H. influenzae | 957 (11) | 7 (4.5) | 0 | 52 (6.4) | 22 (12) | 185 (15) | 32 (15) | 373 (12) | 78 (14) | 157 (7.3) | 51 (12) |
| 2 pathogens | |||||||||||
| S. pneumoniae, H. influenzae | 128 (1.4) | 0 | 0 | 1 (0.12) | 2 (1.1) | 10 (0.8) | 0 | 50 (1.6) | 9 (1.7) | 49 (2.3) | 7 (1.7) |
| S. pneumoniae, M. catarrhalis | 37 (0.4) | 0 | 0 | 17 (2.1) | 3 (1.6) | 5 (0.4) | 1 (0.45) | 4 (0.13) | 1 (0.19) | 5 (0.23) | 1 (0.24) |
| S. pneumoniae, P. aeruginosa | 51 (0.6) | 0 | 0 | 1 (0.12) | 0 | 0 | 0 | 8 (0.25) | 3 (0.56) | 35 (1.6) | 4 (0.94) |
| H. influenzae, M. catarrhalis | 115 (1.3) | 0 | 0 | 2 (0.24) | 1 (0.54) | 14 (1.1) | 7 (3.2) | 54 (1.7) | 20 (3.7) | 13 (0.60) | 4 (0.94) |
| H. influenzae, P. aeruginosa | 41 (0.5) | 0 | 0 | 1 (0.12) | 0 | 1 (0.08) | 2 (0.91) | 26 (0.82) | 7 (1.3) | 3 (0.14) | 1 (0.24) |
| M. catarrhalis, P. aeruginosa | 39 (0.4) | 0 | 0 | 2 (0.24) | 0 | 4 (0.32) | 4 (1.8) | 8 (0.25) | 8 (1.5) | 8 (0.37) | 5 (1.2) |
| 3 pathogens | |||||||||||
| S. pneumoniae, H. influenzae, M. catarrhalis | 32 (0.4) | 0 | 0 | 2 (0.24) | 0 | 2 (0.16) | 1 (0.45) | 6 (0.19) | 0 | 19 (0.88) | 2 (0.47) |
| S. pneumoniae, H. influenzae, P. aeruginosa | 3 (0.03) | 0 | 0 | 0 | 0 | 0 | 0 | 1 (0.03) | 1 (0.19) | 1 (0.05) | 0 |
| S. pneumoniae, M. catarrhalis, P. aeruginosa | 2 (0.02) | 0 | 0 | 0 | 0 | 0 | 0 | 1 (0.03) | 0 | 0 | 1 (0.24) |
| H. influenzae, M. catarrhalis, P. aeruginosa | 1 (0.01) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (0.19) | 0 | 0 |
a
Bacterial cultures were missing for 110 subject visits.
b
Exac, exacerbation.