. 2018 Sep 25;56(10):e00832-18. doi: 10.1128/JCM.00832-18

TABLE 2.

Population-specific determination of sensitivity and specificity of the SHC test performance compared to TR assays only or with a laboratory test panel consensus that includes both TR and NTR assays

Population^a	Assay results					Sensitivity (95% CI)		Specificity (95% CI)
		Treponemal only^b		Test panel consensus^c		Treponemal only	Test panel consensus^c	Treponemal only	Test panel consensus^c
	SHC	TR+	TR−	TR+/NTR+	TR−/NTR−	Treponemal only	Test panel consensus^c	Treponemal only	Test panel consensus^c
Age (yrs)
11–20	+	181	4	141	4	0.896 (0.845, 0.934)	0.972 (0.931, 0.992)	0.927 (0.824, 0.980)	0.922 (0.811, 0.978)
11–20	−	21	51	4	47	0.896 (0.845, 0.934)	0.972 (0.931, 0.992)	0.927 (0.824, 0.980)	0.922 (0.811, 0.978)
21–30	+	134	3	103	3	0.843 (0.777, 0.896)	0.963 (0.907, 0.990)	0.880 (0.688, 0.975)	0.875 (0.676, 0.973)
21–30	−	25	22	4	21	0.843 (0.777, 0.896)	0.963 (0.907, 0.990)	0.880 (0.688, 0.975)	0.875 (0.676, 0.973)
≤31	+	191	34	166	33	0.917 (0.877, 0.947)	0.946 (0.910, 0.971)	0.933 (0.908, 0.953)	0.934 (0.909, 0.954)
≤31	−	18	474	9	468	0.917 (0.877, 0.947)	0.946 (0.910, 0.971)	0.933 (0.908, 0.953)	0.934 (0.909, 0.954)
Sex
Female	+	182	10	119	10	0.831 (0.775, 0.878)	0.937 (0.880, 0.972)	0.926 (0.868, 0.964)	0.924 (0.865, 0.963)
Female	−	37	125	8	122	0.831 (0.775, 0.878)	0.937 (0.880, 0.972)	0.926 (0.868, 0.964)	0.924 (0.865, 0.963)
Male	+	301	1	269	0	0.907 (0.870, 0.936)	0.968 (0.939, 0.985)	0.900 (0.555, 0.997)	1.000 (0.478, 1.000)
Male	−	31	9	9	5	0.907 (0.870, 0.936)	0.968 (0.939, 0.985)	0.900 (0.555, 0.997)	1.000 (0.478, 1.000)
Pregnancy status
Nonpregnant	+	46	0	42	0	0.780 (0.653, 0.877)	0.875 (0.749, 0.953)	1.000 (0.478, 1.000)	1.000 (0.292, 1.000)
Nonpregnant	−	13	5	6	3	0.780 (0.653, 0.877)	0.875 (0.749, 0.953)	1.000 (0.478, 1.000)	1.000 (0.292, 1.000)
Pregnant	+	96	10	39	10	0.814 (0.731, 0.879)	0.951 (0.835, 0.994)	0.923 (0.863, 0.962)	0.922 (0.862, 0.962)
Pregnant	−	22	120	2	119	0.814 (0.731, 0.879)	0.951 (0.835, 0.994)	0.923 (0.863, 0.962)	0.922 (0.862, 0.962)
HIV positive	+	18	4	3	4	0.667 (0.460, 0.835)	0.600 (0.147, 0.947)	0.923 (0.815, 0.973)	0.922 (0.811, 0.978)
HIV positive	−	9	48	2	47	0.667 (0.460, 0.835)	0.600 (0.147, 0.947)	0.923 (0.815, 0.973)	0.922 (0.811, 0.978)

A total of 1,406 sample results were stratified based on age, sex, pregnancy, and HIV status. Populations may overlap across categories. For a given category, not all information was available for the remaining categories.

TR assays include TP-PA, EIA, and CIA platforms.

Test panel consensus refers to results that were either reactive by both treponemal and nontreponemal (RPR) tests or nonreactive by both treponemal and nontreponemal tests; discordant treponemal and nontreponemal results were excluded from analysis.