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. 2018 Sep 25;8:14323. doi: 10.1038/s41598-018-32737-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The phase diagram of deterministic model in the (a, b) parameters plane. The five regions in the phase plane correspond to (M), (E), (E, M), (E, E/M), and (E, E/M, M) states of cancer cell, respectively. The pink dotted line corresponds to one possible EMT process, and the green dotted line corresponds to the other possible EMT process with the increasing of parameter a. The blue dotted line corresponds to a possible MET process with the decreasing of parameter a.