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. 2018 Jul 30;17(5):e12821. doi: 10.1111/acel.12821

Figure 1.

Figure 1

Striatal fast‐spiking (FS) but not cholinergic (ACh) interneurons require DA SNpc for postnatal survival. (a) Schematic representation of the striatal modulatory circuit. Solid lines represent neuronal connectivity and dashed lines neurotrophism. VM, ventral mesencephalon. (b) Schematic representation of the Th‐Shdh mouse model, where a degeneration of the DA SNpc cell bodies and projections is observed (Diaz‐Castro et al., 2012). (c) Brain coronal striatal sections immunostained with anti‐PV (upper panels), a marker of FS interneurons and anti‐ChAT (lower panels), a marker of ACh interneurons antibodies from 8‐month‐old control (left) and Th‐Sdhd (right) mice. Scale bars: 25 µm. Graphs represent the total striatal number of FS (upper panels) and ACh (lower panels) interneurons measured by stereological methods from control (black bars) and Th‐Sdhd (green bars) mice. In the entire figure, values represent mean ± SEM n = 6 per group. *p < 0.05 (Student's t test).