Figure 3.

Signalling pathway involved in enhanced BMP4‐induced osteogenesis by Lox inhibition or CHOP‐10 overexpression. A, The effect of Lox knockdown on p38 MAPK and Smad signalling. B, The effect of Lox knockdown on Wnt/β‐catenin signalling. C, D, The effect of IWR‐1‐endo (5 μmol/L) on Lox inhibition enhanced osteogenic lineage commitment and subsequential differentiation. E, The effect of CHOP‐10 overexpression on p38 MAPK and Smad signalling. F, The effect of CHOP‐10 overexpression on Wnt/β‐catenin signalling. G, H, The effect of IWR‐1‐endo (5 μmol/L) on CHOP‐10 overexpression enhanced osteogenic lineage commitment and subsequential differentiation