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. 2018 Sep 19;12:648. doi: 10.3389/fnins.2018.00648

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Copyright © 2018 Ferlauto, D’Angelo, Vagni, Airaghi Leccardi, Mor, Cuttaz, Heuschkel, Stoppini and Ghezzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Pictures of a fabricated g-MEA with 400 μm diameter electrodes. The scale bar is 400 μm. (B) Schematic of the soft CA-based electrode structure. (C) Step-by-step coating process of the CA-based electrodes. (D) Selective electroplating of alginate with added Rhodamine B on the central Pt electrode only. The scale bar is 150 μm. (E) AFM topography map of a 3 × 3 μm surface area of the CA (left) and the corresponding elastic modulus surface map (right). The scale bar is 400 nm. (F) Quantification of the mean (± SEM) stiffness and variance (n = 6 electrodes, 1 map per electrode).