Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 19;12:311. doi: 10.3389/fncel.2018.00311

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Luján, Aguado, Ciruela, Arus, Martín-Belmonte, Alfaro-Ruiz, Martínez-Gómez, de la Ossa, Watanabe, Adelman, Shigemoto and Fukazawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Spatial relationship between SK2, Ca_V2.1 and mGlu_1α in PCs. (A) Example showing random simulation of immunoparticles for Ca_V2.1 in a dendritic spine. (B) Example showing random simulation of immunoparticles for Ca_V2.1 in a dendritic shaft. Red, real SK2; blue, real Cav2.1; green, simulated Cav2.1. (C) Cumulative probability plot of NND from SK2 to Ca_V2.1 particles in dendrites (blue) and spines (red). Solid: real NND between SK2 and Ca_V2.1; Dashed: simulated NND. The SK2 to Ca_V2.1 NNDs were significantly smaller than the random NNDs in dendritic shafts and spines (p < 0.05, pairwise Mann–Whitney U test, numbers of profiles analyzed for spines and dendrites should be indicated). (D) Example showing random simulation of immunoparticles for mGlu_1α in a dendritic spine. (E) Example showing random simulation of immunoparticles for mGlu_1α in a dendritic shaft. Red, real SK2; blue, real mGlu_1α; green, simulated mGlu_1α. (F) Cumulative probability plot of NND from SK2 to mGlu_1α particles in dendrites (blue) and spines (red). Solid: real NND between SK2 and mGlu_1α; Dashed NND: simulated. The SK2 to mGlu_1α NNDs were significantly smaller than the random NNDs in dendritic shafts and spines (p < 0.05, pairwise Mann–Whitney U test, numbers of profiles analyzed for spines and dendrites should be indicated). (G,H) Examples showing random simulation of immunoparticles for Ca_V2.1 in dendritic spines. Red, real mGlu_1α; blue, real Cav2.1; green, simulated Cav2.1. (I) Cumulative probability plot of NND between Ca_V2.1 and mGlu_1α particles in spines (blue). Solid: real NND between mGlu_1α and Ca_V2.1; Dashed: simulated. The mGlu_1α to Ca_V2.1 NNDs were significantly smaller than the random NNDs in dendritic spines (p < 0.05, pairwise Mann–Whitney U test, number of profiles analyzed should be indicated).