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. 2018 Sep 19;11:331. doi: 10.3389/fnmol.2018.00331

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Copyright © 2018 Ferguson, Zhang, Wang, Bridges, Harris and Ponomarev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A visualization of the conserved regulation of gene expression networks across the tissues analyzed (liver, amygdala, and PFC) created with Cytoscape 3.2.1. The nodes are modules of the individually constructed networks for each tissue (see Figure 3 for details). Only probes common to all tissues were used to assess module overlap. The edges are the –log(hypergeometric p-values) of the number of overlapping probes between 2 nodes (modules). Edge thickness represents the significance of the overlap between the nodes (modules) – the thicker the line, the more significant the overlap. The nodes (modules) were assessed for enrichment of transposable elements (TEs) and genes differentially expressed at p < 0.05 after systemic treatment with one of 3 PPAR agonists (fenofibrate, tesaglitazar, or bezafibrate) (see methods). Node color represents enrichment with TEs (higher intensity = more enrichment). Node size represents enrichment with PPAR agonist-regulated genes (the larger the node, the more enriched with PPAR agonist-regulated genes).