Table 3.
Top associations of the HLA alleles with adenocarcinoma of Asian ancestry
| Locus | Variant | Frequency | Unconditional analysisa | Model including HLA-DQB1 *0401 + HLA-DRB1*0701 + rs2256919 | |||
|---|---|---|---|---|---|---|---|
| Controlsb | Casesb | OR (95% CI) | P value | OR (95%CI) | P value | ||
| HLA-DQB1 | 04:01 | 0.06 | 0.09 | 1.67 (1.35-2.05) | 1.59 × 10−06 | 1.73 (1.41-2.14) | 2.85 × 10−07 |
| HLA-DRB1 | 07:01 | 0.05 | 0.09 | 1.62 (1.31-2.01) | 5.48 × 10−06 | 1.63 (1.32-2.03) | 5.34 × 10−06 |
| HLA_A (intronic) | rs2256919 | 0.44 | 0.38 | 0.75 (0.67-0.83) | 1.75 × 10−07 | 0.76 (0.68-0.85) | 8.92 × 10−07 |
HLA human leucocyte antigen, OR odds ratio, 95% CI confidence interval
a Obtained from multivariate unconditional logistic regression assuming an additive genetic model with sex and principal components as covariates
b Number of samples included in the analysis: 1192 cases and 1656 controls
The study-wide significant threshold was P = 6 × 10−6 (Bonferroni correction)