Table 4.
The top 20 KEGG pathways with the most number of annotated sequences.
| KEGG ID | Pathways description | DEGs associated with the pathway | All genes associated with the pathway | P-value |
|---|---|---|---|---|
| ko04144 | endocytosis | 153 | 554 | 0.0011 |
| ko00532 | glycosaminoglycan biosynthesis | 15 | 27 | 0.0012 |
| ko00564 | glycerophospholipid metabolism | 42 | 127 | 0.0014 |
| ko04330 | Notch signaling pathway | 45 | 142 | 0.0019 |
| ko00100 | steroid biosynthesis | 14 | 26 | 0.0021 |
| ko04350 | fatty-acid biosynthesis | 9 | 32 | 0.0024 |
| ko04668 | TNF signaling pathway | 60 | 208 | 0.0025 |
| ko00600 | sphingolipid metabolism | 23 | 58 | 0.0027 |
| ko04070 | phosphatidylinositol signaling system | 60 | 210 | 0.0030 |
| ko04530 | tight junction | 84 | 362 | 0.0061 |
| ko04064 | NF-kappa B signaling pathway | 55 | 205 | 0.0119 |
| ko04071 | sphingolipid signaling pathway | 72 | 283 | 0.0125 |
| ko00190 | oxidative phosphorylation | 51 | 363 | 0.0145 |
| ko00562 | inositol phosphate metabolism | 41 | 147 | 0.0166 |
| ko00010 | glycolysis/gluconeogenesis | 34 | 207 | 0.0208 |
| ko04380 | osteoclast differentiation | 63 | 252 | 0.0241 |
| ko04060 | cytokine-cytokine receptor interaction | 70 | 288 | 0.0290 |
| ko04640 | thyroid hormone signaling pathway | 77 | 381 | 0.0295 |
| ko04392 | fatty acid elongation | 8 | 41 | 0.0308 |
| ko00020 | glycerolipid metabolism | 12 | 108 | 0.0335 |