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Ubiquitination regulates activation of AKT kinase. The growth factor IGF‐1 triggers K63‐linked ubiquitination of AKT and it promotes recruitment of AKT to membrane, which subsequently phosphorylated by PDK1 and mTOR. The activated AKT translocates to the nucleus and catalyses the transcription of genes associated with the heart growth and hypertrophy. E3 ligase TRAF6 contributes to Akt kinase activation by promoting K63‐linked polyubiquitination
