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. 2018 Sep 19;9:2102. doi: 10.3389/fimmu.2018.02102

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Copyright © 2018 Roszik, Ring, Wani, Lazar, Yemelyanova, Soliman, Frumovitz and Jazaeri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential targets for combination therapies. Median overall survival ratio of low-low (both below median) and high-high (both above median) expression of gene pairs is depicted as shown by the color legend (A), only p < 0.0001 associations where median expression >5 TPM). Kaplan-Meier plots show the difference between high and low expression for FASN (B) and MMP1 (C) alone, and in combination (D). (E) Displays the overall survival ratio analysis results for the EMT genes (shown in rows) identified by our Ingenuity Pathway Analysis. The JAK1 - LOXL2 (F) and JAK1 - RAB2A (G) combination survival analyses are shown as examples.