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. 2018 Sep 19;9:2078. doi: 10.3389/fimmu.2018.02078

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Copyright © 2018 Lu, Bauman, Arjunaraja, Dorjbal, Milner, Snow and Turvey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The landscape of human germline mutations causing CBM-opathies. Schematic representation of protein domains found in CARD11, BCL10, and MALT1. Red arrows indicate interactions between domains. Annotated are confirmed mutations causing CBM-opathies and where they localize to on the protein. CARD, caspase recruitment domain; RE, repressive element; L, linker; PDZ, postsynaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), zonula occludens-1 protein (zo-1) domain; SH3, SRC homology 3 (SH3); GUK, guanylate kinase domain; S/T, serine/threonine; DD, death domain; Ig, immunoglobulin-like domain.