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. 2018 Sep 19;11:323. doi: 10.3389/fnmol.2018.00323

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Copyright © 2018 Bellon, Wegener, Lescallette, Valente, Yang, Gardette, Matricon, Mouaffak, Watts, Vimeux, Yun, Imamura Kawasawa, Clawson, Blandin, Chaumette, Jay, Krebs, Feuillet and Hosmalin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural responses to dopamine and colchicine exposure on human circulating monocytes transdifferentiated into neural-like cells. (A) Light microscopy photographs before and after treatment. The same cell was photographed before (T = 0 h) and after (T = 1 h) treatment with colchicine 0.5 μM (top), and another cell before and after treatment with dopamine 4 mM (bottom). Scale bars = 20 μm. (B) Bar graph showing a decrease in length of the longest primary neurite of transdifferentiated neuronal-like cells before and after different treatments. Data are expressed as ratios between the length of the longest primary neurite of each cell measured before (T0 h) and after (T1 h) treatment. The mean total length of the primary neurites at T = 0 h was 70 ± 30 μm. (C) Bar graph showing the number of secondary neurites of transdifferentiated neuronal-like cells. Data are expressed as the difference between the number of secondary neurites before (T0 h) or after (T1 h) treatment. The mean number of secondary neurites at T = 0 h was 6.0 ± 5.3. (D) Bar graph showing length of the longest secondary neurite on transdifferentiated neuronal-like cells before and after different treatments. Data are expressed as described in (B). The mean total length of the secondary neurites at T = 0 h was 12 ± 8 μm. Statistics are given mean ± SEM. n = 256 cells. Differences were assessed by one-way ANOVA. *P < 0.05, ***P < 0.001, ****P < 0.0001.