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. 2018 Aug 2;22(10):4913–4921. doi: 10.1111/jcmm.13756

Figure 3.

Figure 3

FHL1 is a downstream target of miR‐483‐3p. A, FHL1 was found up‐regulated in HSCR patients at both mRNA and protein levels. (*P < 0.05) B, The mRNA and protein expression of FHL1 were determined by qRT‐PCR and Western blot after transfected with miR‐483‐inhibitor in 293T and SH‐SY5Y cells. (**P < 0.05) C, Bottom: Sequence alignment of human miR‐483‐3p with 3′‐UTR of FHL1. Mutations in the 3′‐UTR of FHL1. TOP: The firefly luciferase activity in 293T and SH‐SY5Y cells after co‐transfection with reporter construct and miR‐483‐3p mimics (***P < 0.05; **P < 0.05)