Figure 3.

Examples of Epigenetic Modulation of Dysregulated LncRNA Expression in Glioma. A, Epigenetic modulation of lncRNA expression in normal brain development. B, Upper panel: lncRNAs expression are up‐regulated by epigenetic mechanisms: histone modifier p300/CBP protein enhances acetylation of H3K9 at the promoter region of CRNDE gene; gain of H3K4me3 transcriptional activated mark at the promoter region of HOTAIRM1 gene and by direct binding of BRD4 protein—an epigenetic modulator that recognizes acetylated lysine tails of histones and brings the transcriptional machineries to promoter region of HOTAIR gene. Lower panel: epigenetic silencing through methylation of CpG islands at the promoter region of tumour suppressors MEG3 and ADAMTS9‐AS2 in glioma