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. 2018 Aug 29;8(3):355–363. doi: 10.15171/apb.2018.042

Table 2. Composition patents issued in the USA for pharmaceutical cocrystals2 .

US Patent No. Date of issue Assignee Compound(s) Ref.
US6001996 14 Dec, 1999 Eli Lilly & Co., Inc. Complexes of (carba)cephalosporins with parabens 52
US7446107 4 Nov, 2008 TransForm Pharmaceuticals, Inc. Itraconazole; cocrystals with acarboxylic acid 53
US7625910 1 Dec, 2009 Astra Zeneca AB AZD1152; a phosphate prodrug and maleic acid cocrystal 54
US8097592 17 Jan, 2012 Astellas Pharma Inc., Kotobuki Pharmaceutical Co. Ltd. SGLT-2 Inhibitor, l-proline cocrystal 55
US8124603 28 Feb, 2012 Thar Pharmaceutical Meloxicam with various carboxylic acids, aliphatic and aromatic, and maltol and ethyl maltol 56
US8163790 24 Apr, 2012 New Form Pharmaceuticals, Inc. Metronidazole cocrystals with gentisic acid and gallic acid (specific x-ray reflections in each case) and a cocrystal of imipramine HCl and (+)-camphoric acid 57
US20170044176 A1 16 Feb, 2017 Euticals Spa Cocrystal of tiotropium bromide and lactose monohydrate 58
US20170224724 A1 10 Aug, 2017 University Of South Florida Co-crystal (ICC) of lithium with salicylic acid and 1-proline 59
US20170101433 A1 13 Apr, 2017 Amri Sci. Llc. Co-crystal of progesterone and a co-former selected from the group consisting of vanillic acid, benzoic acid, salicylic acid, cinnamic acid, and vanillin. 60