a: belongs to Group 1 after 14 days applying ointment formulation and shows showed tissue healing with complete and mature re-epithelialization, fibroblast proliferation, and collagen fiber. (mag:200×). b: belongs to Group 2 after 14 days applying gel formulation and shows complete and mature epithelization. There was severe fibroplasias (arrow) with high level of collagen fiber. (mag:400×). c: belongs to Group 3 after 14 days applying placebo of ointment formulation and shows incomplete epithelization(arrow) with severe fibrosis and moderate inflammatory cells infiltration. (mag:200×).d: belongs to Group 4 after 14 days applying placebo of gel formulation and shows partial epithelization(arrow).there was moderate fibrosis in wound area. (mag:200×). e: is belonging to Group 5 In which Curcumin and ampicillin solution was applied, after 14 days complete, but thin epithelization (mag:400×) was observed. f: is belonging to Group 6 in which Normal saline was applied and photograph was taken after 14 days. Revealed partial epithelization.(mag:400×) is obvious