Table 1. Mean (SD) skin reactions of 3 rabbits 1 after 3min,1hrs,4 hrs,24 hrs,48 hrs and 72 hrs dermal exposure to proposed Solid Lipid Nanoparticles .

Erythema and Eschar Formation	3min	1hr	4hr	24hr	48hr	72hr	Edema	3min	1hr	4hr	24hr	48hr	72hr
No erythema	0	0	0	0	0	0	No edema	0	0	0	0	0	0
Very slight erythema (barely perceptible)	0	0	0	1	1	1	Very slight edema	0	0	0	0	0	0
Well defined erythema	0	0	0	0	0	0	Slight edema	0	0	0	0	0	0
Moderate to severe erythema	0	0	0	0	0	0	Moderate oedema	0	0	0	0	0	0
Severe erythema	0	0	0	0	0	0	Severe edema	0	0	0	0	0	0
Skin dryness	0	0	0	0	1	0	Weight of Animals :3865±108
Total score:4	0	0	0	1	2	1