Figure 2.

Elimination of p19^ARF‐expressing cells diminished elastase‐induced alveolar collapse. (a) Lung tissues of mice treated as shown in Figure 1a were fixed at 25 cmH₂O and subjected to hematoxylin and eosin staining. Representative images are shown. Bar; 500 μm. (b) Representative enlarged images of mouse lung sections. The area indicated in panel A was enlarged. Bar; 100 μm. (c) Alveolar mean linear intercepts were measured. At least 300 alveoli were counted in each mouse. Bars represent the mean ± SEM. Data were analyzed by a one‐way ANOVA and Tukey–Kramer post hoc analysis. *p < 0.05 and ***p < 0.001