Table 1.
Patient clinical and experimental characteristics for the RNAseq cohort (top panel) and combined cohort (bottom panel)
| RNAseq cohort (n = 23) | DGF (n = 11) | IGF (n = 12) | ||
|---|---|---|---|---|
| Variable | Mean (Min‐Max)/Proportion | Standard deviation (if applicable) | Mean (Min‐Max)/Proportion | Standard deviation (if applicable) |
| Donor gender (males/females) | 6/5 | 5/7 | ||
| Donor age (years) | 55 (40–74) | 17.6 | 53.2 (40–77) | 10.7 |
| Donor serum creatinine at retrieval (µmol/L) | 73.25 (44–125) | 26.6 | 78.64 (41–125) | 25.6 |
| Donor type | ||||
| DBD/DCD | 7/4 | 9/3 | ||
| ECD | 6 | 4 | ||
| DBD‐ECD | 4 | 3 | ||
| DCD‐ECD | 2 | 1 | ||
| Cause of death | ||||
| Intracranial haemorrhage | 7 | 8 | ||
| Hypoxic brain injury | 0 | 2 | ||
| Trauma | 0 | 2 | ||
| Cardiac arrest | 1 | 0 | ||
| Intracranial thrombus | 1 | 0 | ||
| Respiratory failure | 1 | 0 | ||
| Meningitis | 1 | 0 | ||
| Recipient gender (males/females) | 8/3 | 8/4 | ||
| Recipient age (years) | 57.9 (42–72) | 10.1 | 51.1 (35–70) | 10.1 |
| Previous transplantation | 0 | 0 | ||
| HLA Mismatch | ||||
| HLA‐A (0/1/2) | 4/5/2 | 4/6/1 | ||
| HLA‐B (0/1/2) | 2/9/0 | 3/7/1 | ||
| HLA‐DR (0/1/2) | 4/7/0 | 3/7/0 | ||
| Cold ischaemic time (hr) | 12.1 (9–17) | 2.8 | 11.1 (6–20) | 4.5 |
| Warm ischaemic time (min) | 29.3 (21–40) | 6.1 | 31.3 (22–40) | 6.7 |
| T1/2 | from 4 to 21 days | less than 3 days | ||
| Serum creatinine level at 6 months (µmol/L) | 126.7 (89–158) | 2.1 | 104.4 (84–166) | 1.74 |
| Combined patient cohort (N = 55) | Mean (Min‐Max)/Proportion | Standard deviation (if applicable) |
|---|---|---|
| Donor gender (males/females) | 33/22 | |
| Donor age (years) | 50.5 (11–77) | 16.4 |
| Donor serum creatinine at retrieval (µmol/L) | 87.1 (41–195) | 35.7 |
| Ethnicity (Caucasian: Asian) | 54:1 | |
| Donor type | ||
| DBD/DCD | 37/11 | |
| ECD | 34 | |
| DBD‐ECD | 16 | |
| DCD‐ECD | 5 | |
| Cause of death | ||
| Intracranial haemorrhage | 35 | |
| Hypoxic brain injury | 10 | |
| Trauma | 7 | |
| Cardiac arrest | 1 | |
| Intracranial thrombus | 1 | |
| Respiratory failure | 1 | |
| Meningitis | 0 | |
| Donor hypotension (N) | 39 | |
| Donor hypertension (N) | 23 | |
| Recipient gender (males/females) | 32/23 | |
| Recipient age (years) | 54.2 (27–73) | 10.1 |
| Aetiology of Renal Failure | ||
| IgA nephropathy | 9 | |
| Glomerulonephritis | 6 | |
| APKD | 12 | |
| Reflux/obstructive uropathy | 7 | |
| Hypertension | 4 | |
| Diabetes mellitus | 2 | |
| Unknown | 8 | |
| Goodpasture's syndrome | 1 | |
| Anatomical anomalies | 2 | |
| Drug related | 1 | |
| Stone disease | 1 | |
| HUS | 1 | |
| FSGS | 1 | |
| Previous Transplant | ||
| 0 | 45 | |
| 1 | 7 | |
| 2 | 2 | |
| HLA Mismatch | ||
| HLA‐A (0/1/2) | 9/18/10 | |
| HLA‐B (0/1/2) | 10/23/5 | |
| HLA‐DR (0/1/2) | 24/10/0 | |
| Cold ischaemic time (hr) | 12.8 (6–21) | 3.9 |
| Immunosuppression | ||
| Induction | ||
| Basiliximab/campath/ATG | 42/6/6 | |
| Maintenance | ||
| Tacrolimus/Sirol/Cyc | 54/0/1 | |
| Prednisolone | 51 | |
| Mycophenolatemofetil | 55 | |
| BPAR | 1 | |
| DGF | 19 | |
| Serum creatinine level at 6 months (µmol/L) | 131 (61–523) | 74.4 |
| MDRD4 at 6 months (ml min−1 1.73 m−2) | 57.4 (9–102) | 22.3 |
| Serum creatinine level at 12 months (µmol/L) | 137.6 (67–377) | 62.8 |
| MDRD4 at 12 months (ml min−1 1.73 m−2) | 51.1 (10–89) | 20.8 |
Continuous variables are expressed as mean with standard deviation, whereas categorical variables are expressed as proportions.