Table 2.
Multiple dose results for enrofloxacin and ciprofloxacin.
| Multiple dose study (5 mg/kg × 3) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Plasma | ISF | Ileum | Colon | ||||||
| Parameter | Units | Mean | Std Dev | Mean | Std Dev | Mean | Std Dev | Mean | Std Dev |
| CIPROFLOXACIN | |||||||||
| Accumulation Index | (blank) | 1.26 | 0.37 | 1.08 | 0.03 | 1.46 | 0.26 | 1.29 | 0.28 |
| AUC tau | h*μg/mL | 2.99 | 1.41 | 3.78 | 1.01 | 8.02 | 2.10 | 3.85 | 3.18 |
| AUC (0 to Cn) | h*μg/mL | 3.24 | 1.62 | 5.29 | 1.37 | 10.14 | 4.36 | 4.71 | 3.02 |
| AUC (0 to infinity) | h*μg/mL | 3.35 | 1.65 | 5.36 | 1.44 | 13.85 | 5.05 | 4.81 | 3.10 |
| CMAX | μg/mL | 0.25 | 0.10 | 0.21 | 0.06 | 0.52 | 0.14 | 0.31 | 0.24 |
| Half-life | h | 9.82 | 7.24 | 6.25 | 0.97 | 14.13 | 5.08 | 10.41 | 6.25 |
| Elim Rate | 1/h | 0.10 | 0.05 | 0.11 | 0.02 | 0.06 | 0.03 | 0.10 | 0.08 |
| MRT | h | 11.37 | 1.99 | 21.66 | 3.43 | 26.15 | 8.97 | 27.36 | 11.46 |
| Tmax | h | 6.00 | 1.55 | 11.64 | 5.50 | 6.00 | 4.90 | 13.33 | 9.38 |
| Penetration | % | . | . | 196.52 | 98.74 | 340.48 | 143.06 | 186.85 | 162.56 |
| ENROFLOXACIN | |||||||||
| Accumulation Index | (blank) | 1.08 | 0.08 | 1.12 | 0.12 | 1.12 | 0.13 | 1.25 | 0.23 |
| AUC tau | h*μg/mL | 8.57 | 6.48 | 3.17 | 2.14 | 24.27 | 9.49 | 19.09 | 10.51 |
| AUC (0 to Cn) | h*μg/mL | 8.97 | 6.98 | 4.10 | 2.68 | 30.68 | 19.12 | 24.24 | 17.00 |
| AUC (0 to infinity) | h*μg/mL | 9.08 | 7.01 | 4.30 | 2.77 | 37.05 | 17.80 | 34.79 | 16.01 |
| CMAX | μg/mL | 0.84 | 0.54 | 0.20 | 0.14 | 1.66 | 0.67 | 1.11 | 0.59 |
| Half-life | h | 5.78 | 2.56 | 7.07 | 2.79 | 7.05 | 2.94 | 9.97 | 4.49 |
| Elim Rate | 1/h | 0.15 | 0.08 | 0.11 | 0.03 | 0.11 | 0.03 | 0.08 | 0.03 |
| MRT | h | 8.46 | 1.34 | 19.12 | 2.66 | 20.70 | 5.97 | 31.94 | 5.69 |
| TMAX | h | 4.55 | 1.57 | 12.00 | 4.38 | 14.67 | 7.45 | 19.50 | 6.21 |
| Penetration | % | 49.57 | 12.79 | 451.03 | 179.46 | 283.32 | 171.96 | ||
*
Penetration % = AUC tissue/AUC plasma.
AUC, area-under-the-curve (plasma concentration vs. time curve) expressed as 0 to Cn (last time point), or to infinity; CMAX, peak concentration; Elim Rate, elimination rate; Half-life, terminal half-life (T); MRT, mean residence time; TMAX, time of peak concentration; Penetration, extent of penetration (%) from plasma to tissue compartment.