Table 4.
Adverse events among included RCTs.
| References | Groups | GIT manifestation N (%) | Psychiatric disorders N (%) | General condition N (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea | Diarrhea | Constipation | Vomiting | Abdominal pain | Abnormal dreams | Anxiety | Suicidal ideation | Insomnia | Depression | Headache | Fatigue | ||
| Williams et al. (33) | Varenicline | 20 (23.8) | 7 (8.3) | ND | 9 (10.7) | 7 (8.3) | 6 (7.1) | 4 (4.8) | 5 (6) | 8 (9.5) | 4 (4.8) | 9 (10.7) | 5 (6) |
| Placebo | 6 (14) | 2 (4.7) | ND | 4 (9.3) | 1 (2.3) | 4 (9.3) | 4 (9.3) | 3 (7) | 2 (4.7) | 3 (7) | 8 (18.6) | 2 (4.7) | |
| Hong et al. (46) | Varenicline | 10 (31.3) | ND | 5 (15.6) | 5 (15.6) | 9 (28.1) | 3 (9.4) | 7 (21.9) | ND | 9 (28.1) | ND | 3 (9.4) | 13 (40.6) |
| Placebo | 10 (31.3) | ND | 8 (25) | 1 (3.1) | 11 (34.4) | 11 (34.4) | 6 (18.8) | ND | 11 (34.4) | ND | 10 (31.3) | 10 (31.3) | |
| Weiner et al. (19) | Varenicline | 3 (75) | ND | 2 (50) | ND | ND | ND | ND | ND | 3 (75) | ND | ND | ND |
| Placebo | 1 (20) | ND | 0 | ND | ND | ND | ND | ND | 1 (20) | ND | ND | ND | |
ND, not detected.