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. 2018 Sep 19;9:1306. doi: 10.3389/fphys.2018.01306

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Copyright © 2018 Tomek, Tomková, Zhou, Bub and Rodriguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A comparison of fork and eye-type alternans in the ORd model. The left column shows fork alternans in APD (A) and calcium transient amplitude (B), with underlying fractional JSR depletion per action potential (C), computed as: , where min(Ca_JSR) is the minimum JSR contents per action potential and Ca_{JSR, start} is the starting JSR calcium concentration in the same action potential. In panels (D–F) are respectively shown APD, CaT, and depletion in eye-type alternans. All plots show the values of the two last action potentials for every bcl and variable of interest; bifurcation indicates that the last two action potentials differ in the variable of interest, manifesting alternans.

Inline graphic — A comparison of fork and eye-type alternans in the ORd model. The left column shows fork alternans in APD (A) and calcium transient amplitude (B), with underlying fractional JSR depletion per action potential (C), computed as: , where min(Ca_JSR) is the minimum JSR contents per action potential and Ca_{JSR, start} is the starting JSR calcium concentration in the same action potential. In panels (D–F) are respectively shown APD, CaT, and depletion in eye-type alternans. All plots show the values of the two last action potentials for every bcl and variable of interest; bifurcation indicates that the last two action potentials differ in the variable of interest, manifesting alternans.