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. 2018 Sep 25;9(10):1001. doi: 10.1038/s41419-018-1051-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Hematoxylin and eosin (H&E) staining of retinal frozen sections showed less retinal ganglion cells, distorted morphology, and retinal thinning 7 days after IR injury which was further worsened in A1^+/− retinas (yellow arrow heads). Scale bar = 50 μm. GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer. b Quantification of inner retina thickness (GCL + IPL + INL, denoted by yellow arrows in panel (a)), n = 4 for WT IR and 5 for A1^+/− IR, *p < 0.05. c Optical coherence tomography (OCT) in live mice at 7 days corroborated the H&E results with yellow arrow heads pointing at retinal distortion/detachment, n = 3 per group (different cohort of mice than the one used for H&E)