Fig. 4. Myeloid A1 deletion worsens neuronal loss and retinal thinning after IR injury.

a Retinas of mice with myeloid but not endothelial-specific A1 deletion showed worsened neuron loss compared to floxed control at 7 days after IR injury. Scale bar = 100 μm. b Quantification of NeuN-positive cells, n = 9 for A1^f/f IR and 5 for M-A1^−/− and E-A1^−/− IR, *p < 0.05 vs. A1^f/f. c H&E staining at 7 days showed worsened inner retina thinning in M-A1^−/− mice compared to control (A1^f/f). Scale bar = 50 μm. d Quantification of inner retina thickness, n = 7 for A1^f/f IR and 6 for M-A1^−/− IR, *p < 0.05. e Optical coherence tomography (OCT) corroborated the H&E results with yellow arrow pointing at retinal detachment