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. 2018 Sep 25;8:14322. doi: 10.1038/s41598-018-32774-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PbsP-based immunization protects against lethal CC17 GBS infection in mice. (A) Mice were immunized with recombinant PbsP fused to glutathione-S-transferase (GST-PbsP) or with GST as a control and challenged i.v. with 1 × 10⁸ CFU of wild-type CC17 strain BM110. *p < 0.05 by Kaplan-Meier analysis. Shown are the cumulative results of two experiments, each involving 8 mice per group. (B–D) Effects of PbsP immunization on organ bacterial burden after i.v. challenge with 1 × 10⁸ CFU of BM110. **p < 0.01 by the Mann-Whitney U test; ns, non-significant. Shown are cumulative results from 2 experiments, each involving 6 mice per group.