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. 2018 Sep 25;8:14369. doi: 10.1038/s41598-018-32717-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of MSI and CIMP in the AG and GC groups. (A) The data points within the shaded t = 0 region indicate the Hp group. In non-IM, both MSI and CIMP have mostly disappeared after H. pylori eradication in the AG group. The incidence of CIMP increases gradually, but does not show a significant change in the GC group. (B) In IM, the incidence of MSI and CIMP do not show significant changes after treatment in the AG group. The incidence of CIMP remains persistently high in the GC group.