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. 2018 Sep 25;9:3925. doi: 10.1038/s41467-018-06407-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — FAM35A and C20ORF196 promote NHEJ to repair DSB. a, b Sensitivity assay of FAM35A (a) and C20ORF196 (b) knockout DT40 cells. The mean and s.d. from three independent experiments are shown. c Random integration assay of FAM35A and C20ORF196 knockout DT40 cells. Cells were transfected with the pLoxPuro plasmid and clonogenic potential was determined in the presence of puromycin. Data are expressed as the mean number of puromycin resistant colonies ± s.d. (n = 3). d Sensitivity assay of FAM35A^−/− cells re-expressing GFP-fused wild-type or mutated chicken FAM35A. Protein expression levels of GFP-chFAM35A were shown by immunoblotting on the bottom