Table 1.
Cage size | ΔGunfold, kcal/mol | kunfold, s−1 | x†, nm | ΔG†unfold, kcal/mol |
No cage | 7.10 ± 0.48 | 5.76 ± 0.38 × 10−3 | 0.21 ± 0.05 | 10.86 ± 0.70 |
15 × 15 nm | 7.78 ± 0.80 | 1.31 ± 0.01 × 10−3 | 0.24 ± 0.01 | 12.07 ± 0.04 |
12 × 12 nm | 9.69 ± 1.16 | 5.21 ± 2.60 × 10−4 | 0.25 ± 0.01 | 14.85 ± 0.44 |
9 × 9 nm | 11.30 ± 0.99 | 3.09 ± 3.43 × 10−8 | 0.56 ± 0.08 | 16.82 ± 0.22 |
ΔGunfold, change in free energy of unfolding; ΔGunfold†, activation energy of unfolding; kunfold, unfolding rate constant; x†, distance between the folded and the transition states. Error bars represent SDs.