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. 2018 Sep 4;115(38):9539–9544. doi: 10.1073/pnas.1805939115

Table 1.

Thermodynamic (ΔGunfold) and kinetic (ΔGunfold and kunfold) parameters for the telomeric i-motif within and without nanocages

Cage size ΔGunfold, kcal/mol kunfold, s−1 x, nm ΔGunfold, kcal/mol
No cage 7.10 ± 0.48 5.76 ± 0.38 × 10−3 0.21 ± 0.05 10.86 ± 0.70
15 × 15 nm 7.78 ± 0.80 1.31 ± 0.01 × 10−3 0.24 ± 0.01 12.07 ± 0.04
12 × 12 nm 9.69 ± 1.16 5.21 ± 2.60 × 10−4 0.25 ± 0.01 14.85 ± 0.44
9 × 9 nm 11.30 ± 0.99 3.09 ± 3.43 × 10−8 0.56 ± 0.08 16.82 ± 0.22

ΔGunfold, change in free energy of unfolding; ΔGunfold, activation energy of unfolding; kunfold, unfolding rate constant; x, distance between the folded and the transition states. Error bars represent SDs.