Fig. 2.

Relationship of blood immunoglobulin levels with TNFα and need for IgRT. A. Plasma was collected from 43 patients. Serum IgG was determined by the Sunnybrook Clinical Laboratory and plasma TNFα was measured by Multiplexing LASER Bead Technology. An iterative algorithm was used to group the samples, depending on whether they contained more or <7.5 g/L IgG. B. Ig levels at time of initial CLL diagnosis were recorded for 109 patients including 19 who were commenced ultimately on Ig RT. Low (lo) IgA, IgG, and IgM were defined as <0.7, 6.0, and 0.4 g/L, respectively.