Fig. 3.

Plasma TNFα and β2-microglobulin (β2M) changes in CLL patients following institution of Ig replacement therapy. A. Examples of time courses of IgG and β2M levels along with lymphocyte numbers following institution of IgRT to IgG levels of ~ 6 g/L (upper panels) or 12 g/L (lower panels). B,C. TNFα levels were measured in plasma samples collected incidentally from 11 patients over a 3 year period (2015–17) prior to and at varying times after starting IVIG or Hizentra (B). β2M levels before and after starting IgRT were taken from the clinical records from these and an additional 10 patients (C). The time between the two plasma collections for each patient is indicated in the figure legends. Patient samples were grouped according to IgG level achieved by IgRT at time of sample collection, using 9 g/L as a cut-off. D. Summary graph of average change in serum β2M for each group indicating an IgG level > 9 g/L is significantly associated with a lowering of β2M levels. *, p < 0.05.