Table 1.

Univariate and multivariate cox analyses in gliomas.

Factor	CGGA RNA-seq set					TCGA RNA-seq set
		Univariate		Multivariate			Univariate		Multivariate
	sample	P value	HR	P value	HR	sample	P value	HR	P value	HR
Age
Increasing years	310	<0.001	1.038	0.961	1.000	678	<0.001	1.066	<0.001	1.036
Gender
Male vs. Female	310	0.345	0.847			678	0.061	1.262
WHO Grade
Grade II	105	Ref.	Ref.	Ref.	Ref.	222	Ref.	Ref.	Ref.	Ref.
Grade III	67	<0.001	5.865	<0.001	4.150	242	<0.001	2.986	0.003	1.961
Grade IV	138	<0.001	14.710	<0.001	49.383	167	<0.001	18.593	<0.001	4.988
Histopathology				a					a
Oligodendroglioma	39	Ref.	Ref	Ref.	Ref.	180	Ref.	Ref.	Ref.	Ref.
Oligoastrocytoma	67	0.007	7.294	0.012	6.591	116	0.262	1.322	0.043	1.670
Astrocytoma	66	<0.001	13.909	0.002	10.598	168	0.008	1.774	0.102	1.444
Glioblastoma	138	<0.001	44.882	b		167	<0.001	12.726	b
TCGA molecular classification
Neural	76	ref	Ref	Ref.	Ref.	134	Ref.	Ref.	Ref.	Ref.
Proneural	99	0.009	2.182	0.273	1.477	345	0.424	0.843	0.450	0.837
Classical	70	<0.001	6.194	0.466	1.282	98	<0.001	5.326	0.258	0.733
Mesenchymal	65	<0.001	10.793	0.169	1.733	114	<0.001	6.023	0.699	0.895
Radiation
Yes vs. No	287	<0.001	0.429	<0.001	0.454
Chemotherapy
Yes vs. No	279	0.079	0.852
IDH status
Mutation vs. wild-type	310	<0.001	0.244	0.240	0.702	668	<0.001	0.117	<0.001	0.375
CMTM6
Increasing expression	310	<0.001	1.105	0.013	1.047	678	<0.001	1.088	0.030	1.029

^aDegree of freedom reduced because of constant or linearly dependent covariates.

^bConstant or Linearly Dependent Covariates Glioblastoma = Grade IV.