Table V.
Relationship between Caco-2 Permeability Values for Passively Permeating Compounds Obtained using Either pH 7.4 Buffer or Human Plasma and Human Fraction Absorbed Values. Papp50 is the Permeability Coefficient Associated with 50% Fraction Absorbed and γ is the Hill Slope. Regression Parameters Represent the Best Fit to a Sigmoidal Equation ± Standard Error of the Estimate
| Regression Parameters (Papp X 106 cm/s) | Permeability Classificationa (Papp X 106 cm/s) | ||
|---|---|---|---|
| Caco-2 Papp (pH 7.4 buffer) This work |
Papp50 0.839 ± 0.202 γ 0.982 ± 0.259 |
Low Int High |
Papp < 0.839 0.839 ≤ Papp < 4.90 Papp ≥ 4.90 |
| Caco-2 Papp (human plasma) This work |
Papp50 1.29 ± 0.213 γ 0.942 ± 0.173 |
Low Int High |
Papp < 1.29 1.29 ≤ Papp < 8.15 Papp ≥ 8.15 |
| Caco-2 Papp (pH 7.4 Buffer) Stenberg et al. (36) |
Papp50 0.705 ± 0.079 γ 1.34 ± 0.200 |
Low Int High |
Papp < 0.705 0.705 ≤ Papp < 2.57 Papp ≥ 2.57 |
aUsing the criteria of low (FA <50%), intermediate (FA 50–84%), and high (FA ≥ 85%) as per reference (7)