. 2018 Jun 7;45(5):675–688. doi: 10.1007/s11033-018-4204-x

Table 3.

Top canonical pathways of up-regulated genes as demonstrated by interactive pathway analysis (IPA)

DAN	ILI	BOR
1. Acute phase response signaling 8.43E−11^a, 36/169 (0.213)^b	1. Agranulocyte adhesion and diapedesis 2.21E−16, 40/189 (0.212)	1. Agranulocyte adhesion and diapedesis 3.52E−12, 27/189 (0.143)
2. FXR/RXR activation 1.78E−10, 30/126 (0.238)	2. Granulocyte adhesion and diapedesis 3.93E−12, 33/177 (0.186)	2. Integrin signaling 2.81E−09, 25/219 (0.114)
3. Agranulocyte adhesion and diapedesis 9.04E−08, 33/189 (0.175)	3. Leukocyte extravasation signaling 1.81E−09, 32/210 (0.152)	3. Granulocyte adhesion and diapedesis 5.19E−09, 22/177 (0.124)
4. LXR/RXR activation 1.18E−07, 25/121 (0.207)	4. Interferon signaling 2.82E−09, 13/36 (0.361)	4. Leukocyte extravasation signaling 5.71E−09, 24/210 (0.114)
5. Tight junction signaling 1.81E−07, 30/167 (0.18)	5. iNOS signaling 4.52E−08, 13/44 (0.295)	5. ILK signaling 7.14E−09, 23/196 (0.117)

DAN

ILI

BOR

1. Acute phase response signaling

8.43E−11^a, 36/169 (0.213)^b

1. Agranulocyte adhesion and diapedesis

2.21E−16, 40/189 (0.212)

1. Agranulocyte adhesion and diapedesis

3.52E−12, 27/189 (0.143)

2. FXR/RXR activation

1.78E−10, 30/126 (0.238)

2. Granulocyte adhesion and diapedesis

3.93E−12, 33/177 (0.186)

2. Integrin signaling

2.81E−09, 25/219 (0.114)

3. Agranulocyte adhesion and diapedesis

9.04E−08, 33/189 (0.175)

3. Leukocyte extravasation signaling

1.81E−09, 32/210 (0.152)

3. Granulocyte adhesion and diapedesis

5.19E−09, 22/177 (0.124)

4. LXR/RXR activation

1.18E−07, 25/121 (0.207)

4. Interferon signaling

2.82E−09, 13/36 (0.361)

4. Leukocyte extravasation signaling

5.71E−09, 24/210 (0.114)

5. Tight junction signaling

1.81E−07, 30/167 (0.18)

5. iNOS signaling

4.52E−08, 13/44 (0.295)

5. ILK signaling

7.14E−09, 23/196 (0.117)

^ap-Value

^bPathway ratio