. 2018 Jun 7;45(5):675–688. doi: 10.1007/s11033-018-4204-x

Table 4.

Top canonical pathways of down-regulated genes as demonstrated by interactive pathway analysis (IPA)

DAN	ILI	BOR
1. Glucocorticoid receptor signaling 1.24E−12^a, 57/287 (0.199)^b	1. Integrin signaling 4.39E−06, 23/219 (0.105)	1. EIF2 signaling 1.56E−10, 26/194 (0.134)
2. Regulation of eIF4 and p70S6K signaling 3.70E−12, 39/157 (0.248)	2. Glucocorticoid receptor Signaling 5.45E−06, 27/287 (0.094)	2. Regulation of eIF4 and p70S6K signaling 2.38E−07, 19/157 (0.121)
3. mTOR signaling 1.56E−10, 42/199 (0.211)	3. EIF2 signaling 7.08E−06, 21/194 (0.108)	3. mTOR signaling 2.29E−06, 20/199 (0.101)
4. Production of nitric oxide and reactive oxygen species in macrophages 8.85E−09, 38/193 (0.197)	4. Regulation of eIF4 and p70S6K signaling 1.44E−05, 18/157 (0.115)	4. Cell cycle: G1/S checkpoint regulation 6.08E−04, 8/64 (0.125)
5. EIF2 signaling 1.03E−08, 38/194 (0.196)	5. Adipogenesis pathway 9.61E−05, 15/134 (0.112)	5. Antiproliferative role of TOB in T cell signaling 9.08E−04, 5/26 (0.192)

DAN

ILI

BOR

1. Glucocorticoid receptor signaling

1.24E−12^a, 57/287 (0.199)^b

1. Integrin signaling

4.39E−06, 23/219 (0.105)

1. EIF2 signaling

1.56E−10, 26/194 (0.134)

2. Regulation of eIF4 and p70S6K signaling

3.70E−12, 39/157 (0.248)

2. Glucocorticoid receptor Signaling

5.45E−06, 27/287 (0.094)

2. Regulation of eIF4 and p70S6K signaling

2.38E−07, 19/157 (0.121)

3. mTOR signaling

1.56E−10, 42/199 (0.211)

3. EIF2 signaling

7.08E−06, 21/194 (0.108)

3. mTOR signaling

2.29E−06, 20/199 (0.101)

4. Production of nitric oxide and reactive oxygen species in macrophages

8.85E−09, 38/193 (0.197)

4. Regulation of eIF4 and p70S6K signaling

1.44E−05, 18/157 (0.115)

4. Cell cycle: G1/S checkpoint regulation

6.08E−04, 8/64 (0.125)

5. EIF2 signaling

1.03E−08, 38/194 (0.196)

5. Adipogenesis pathway

9.61E−05, 15/134 (0.112)

5. Antiproliferative role of TOB in T cell signaling

9.08E−04, 5/26 (0.192)

^ap-Value

^bPathway ratio