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. 2018 Jun 7;45(5):675–688. doi: 10.1007/s11033-018-4204-x

Table 6.

Top canonical pathways of down-regulated genes involved in immunological processes as demonstrated by interactive pathway analysis (IPA)

DAN ILI BOR

1. Production of nitric oxide and reactive oxygen species in macrophages

8.85E−08a, 38/193 (0.197)b

1. Regulation of IL-2 expression in activated and anergic T lymphocytes

5.16E−04, 10/79 (0.127)

1. Antiproliferative role of TOB in T cell signaling

9.08E−04, 5/26 (0.192)

2. B cell receptor signaling

2.97E−08, 36/185 (0.195)

2. PI3K signaling in B lymphocytes

7.06E−04, 13/128 (0.102)

2. PI3K signaling in B lymphocytes

5.04E−03, 10/128 (0.078)

3. IL-15 signaling

4.69E−08, 21/76 (0.276)

3. NF-κB signaling

8.02E−04, 16/180 (0.089)

3. Production of nitric oxide and reactive oxygen species in macrophages

1.33E−02, 12/193 (0.062)

4. NF-κB signaling

4.7E−08, 35/180 (0.194)

4. B cell receptor signaling

1.07E−03, 16/185 (0.086)

4. T helper cell differentiation

1.91E−02, 6/71 (0.085)

5. CD40 signaling

7.68E−08, 21/78 (0.269)

5. CD40 signaling

1.89E−03, 9/78 (0.115)

5. B cell receptor signaling

2.33E−02, 11/185 (0.059)

ap-Value

bPathway ratio