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. Author manuscript; available in PMC: 2018 Sep 26.
Published in final edited form as: Crit Rev Immunol. 2018;38(2):79–103. doi: 10.1615/CritRevImmunol.2018025653

Table 1.

Tissue-specific features of CD8+ TRMs.

Local Ag TGF-β IL-15 Xcr-1+DC CD4-help Unique Effector
Skin N.R., but promote Required* Required Required N.R. ? IL-17 from a subset
Lung Required Required* Required Required Required IL-22
URT N.R. N.R. Unknown Unknown Unknown Unknown
SI N.R./Suppress Required* N.R. Unknown Unknown Type I/III IFN
FRT N.R. Unknown N.R. Unknown Required Unknown
Kidney Unknown Promote Required Unknown Unknown Unknown
SG N.R. Required* Required Unknown Unknown Unknown
Liver Required Maybe Maybe Unknown Unknown CSF-2
Brain Required Maybe Maybe Unknown N.R. Unknown
WAT Unknown Unknown Maybe Unknown Unknown Unknown

URT, Upper respiratory tract; SI, Small intestine; FRT, Female reproductive tract; SG, Salivary gland; WAT, White adipose tissue.

Ag, Antigen; N.R., not required.

*

, TGF-β is required for CD103+ TRM, but not for CD69+CD103− TRM.

?

, The involvement of CD4-help in skin TRM formation may require future investigation.